Repair of Isoaspartyl Residues by PCMT1 and Kidney Fibrosis

Kidney tissues from mice and humans were evaluated for protein L-isoaspartyl/D-aspartyl methyltransferase (PCMT1) expression and its association with fibrosis and kidney function. PCMT1’s effects on the TGF-β1/Smad signaling were analyzed, and its functional role was assessed in tubule-specific Pcmt1 knockout murine models of kidney fibrosis.