Novel Post-Translational Modification Learning Signature Reveals B4GALT2 as an Immune Exclusion Regulator in Lung Adenocarcinoma

Suppression of beta-1,4-galactosyltransferase 2 (B4GALT2) was found to enhance CD8+ T lymphocyte populations and their functional status, thereby potentiating anti-programmed cell death protein 1 immunotherapeutic efficacy in animal studies.