Transcription Factor ELF-1 Protects against Colitis by Maintaining Intestinal Epithelium Homeostasis

Researchers demonstrated that E74-like factor 1 (ELF-1) deficiency in mice led to exacerbated DSS-induced colitis, marked by inflammation dominated by neutrophil infiltration and activation of IL-17 signaling pathways in various immune cells, including Th17, ILC3, γδT, and NKT cells.