Periarteriolar Niches Become Inflamed in Aging Bone Marrow, Remodeling the Stromal Microenvironment, and Depleting Lymphoid Progenitors

Scientists performed single-cell RNA sequencing of mouse bone marrow stromal cells. They identified five transcriptionally distinct subsets of Leptin receptor–expressing cells, all of which expressed the highest levels of Stem Cell Factor and Cxcl12 in bone marrow throughout adult life.