Origin and Cell Type Specificity of Mitochondrial DNA Mutations in C9ORF72 ALS-FTLD Human Brain Organoids

Investigators generated cerebral organoids derived from hiPSCs of patients with ALS-frontotemporal lobar degeneration (FTLD) harboring the C9ORF72 hexanucleotide repeat expansion alongside CRISPR-corrected isogenic and healthy controls.