mpECs with High Piezo2 Expression Promote Fracture Healing by Driving Angiogenesis through the Notch Signaling Pathway

The roles of different endothelial cell (EC) subsets in fracture healing were observed using scRNA-seq. It was found that metaphyseal ECs (mpECs) did affect the repair and regeneration of fracture sites, and could up-regulate genes related to the Notch signaling, angiogenesis, and cell cycle.