Induction of LY6E Regulates Interleukin-1β Production, Potentially Contributing to the Immunopathogenesis of Systemic Lupus Erythematosus

By studying mouse bone marrow-derived macrophages, researchers showed that LY6E regulated IFN-α- and IC-induced production and secretion of mature interleukin-1β, foam cell formation, and several mitochondria-associated mechanisms.