Cell-Autonomous Dysregulation of Interferon Signaling Drives Clonal Expansion of SRSF2-Mutant MDS Stem/Progenitor Cells

Using human isogenic iPSC-based models of SRSF2-mutant myelodysplastic syndromes (MDS) and primary MDS patient cells, scientists showed that the SRSF2 P95L mutation downregulated basal STAT1 expression.