OGT Prevents DNA Demethylation and Suppresses the Expression of Transposable Elements in Heterochromatin by Restraining TET Activity Genome-Wide

Scientists showed that deletion of the Ogt gene in mESC results in a widespread increase in the TET product 5-hydroxymethylcytosine in both euchromatic and heterochromatic compartments, with a concomitant reduction in the TET substrate 5-methylcytosine at the same genomic regions.