Menthol, a Consumer Product Additive, Adversely Affects Human Embryonic Stem Cells via Activation of TRPM8, and TRPA1 Channels

hESCs were used to test the hypothesis that 6.4-640 nM and 19.2-192 µM menthol, which activates transient-receptor-potential (TRP) channels, altered calcium homeostasis in embryos and adversely affected processes that are critical to gastrulation.