Targeted Release of a Bispecific Fusion Protein SIRPα/Siglec-10 by Oncolytic Adenovirus Reinvigorates Tumor-Associated Macrophages to Improve Therapeutic Outcomes in Solid Tumors

To identify the characteristics of recombinant adenovirus-SIRPα/Siglec-10, investigators conducted CCK8 assay, quantitative PCR, western blot, competitive binding assay, in vitro cytotoxicity assay, ELISA and phagocytosis assay.