CDX2 Downregulation Regulates Intrinsic WNT Pathway Activation, Dictating Metastasis in APC, and CTNNB1 Wildtype Colorectal Cancer

Investigators compared two distinct in vitro KPN models, organoids and tumoroids. The organoid model only carried the original mutations, while the tumoroids were derived from in vivo grown tumors that underwent selection during development.