Wolfram Syndrome 2 Gene (CISD2) Deficiency Disrupts Ca²⁺-Mediated Insulin Secretion in β-Cells

Scientists delineated the essential role of CISD2 in β-cells. β-cell specific Cisd2 knockout in mice disrupted systemic glucose homeostasis via impairing β-granules synthesis and insulin secretion; hypertrophy of the β-islets and the presence of a loss of identity that affects certain β-cells.