CAR Treg Synergy with Anti-CD154 Promotes Infectious Tolerance and Dictates Allogeneic Heart Transplant Acceptance

Using an HLA-A2–transgenic haplo-mismatched heart transplantation model in immunocompetent C57BL/6 recipients, scientists showed that HLA-A2–specific CAR Tregs were able to synergize with a low dose of anti-CD154 to enhance graft survival.