Ultrasound-Mediated Biomimetic Microbubbles Effectively Reverse LSECs Capillarization and Exert Antiplatelet Therapy in Liver Fibrosis

A type of multifunctional liposomal microbubbles carrying both Sim and platelet membrane had been designed for drug delivery targeting the inflammatory liver sinusoidal endothelial cells, with ultrasound-targeted microbubble destruction to mediate efficient release of these therapeutic agents inside the liver sinusoidal.