METTL3 Obstructs Vascular Smooth Muscle Cells Osteogenic Reprogramming by Methylating Runx2 in Chronic Kidney Disease

Researchers discovered that serum N6-methyladenosine (m6A) levels in RNA were dramatically reduced as vascular calcification progressed in patients with chronic kidney disease, and this m6A demethylation was mainly due to the downregulation of methyltransferaselike-3 (METTL3).