Validation and Derivation of MicroRNA-Based Germline Signatures Predicting Radiation Toxicity in Prostate Cancer

Scientists validated a previously identified biomarker of late radiation therapy (RT)-induced genitourinary (GU)toxicity, PROSTOX, consisting primarily of microRNA-based germline biomarkers (mirSNPs), and investigated the possibility of temporally and genetically defining other forms of RT-associated GU toxicity.