The TRIB2-DNMT1 Pathway Generates an Immune Cold Microenvironment in Glioblastoma and Its Inhibition Promotes Immunotherapy

Investigators identified regulators of low CD8⁺ T-cell infiltration in glioblastoma (GBM). Using transcriptomic screening, they found that TRIB2 was a regulator of the immune-cold microenvironment characteristic of GBM.