Multifaceted Roles of OCT4 in Tumor Microenvironment: Biology and Therapeutic Implications

The authors review recent evidence showing that OCT4 expressed in cancer stem cells plays a multifaceted role in shaping the TME by interacting with the cellular TME components, including cancer-associated fibroblasts, tumor endothelial cells, tumor-infiltrating immune cells, as well as the non-cellular TME components, such as ECM.