STING Aggravates Ferroptosis-Dependent Myocardial Ischemia-Reperfusion Injury by Targeting GPX4 for Autophagic Degradation

The authors discovered that during myocardial ischemia-reperfusion, double-stranded DNA-cyclic GMP-AMP synthase-stimulator of interferon genes (STING) signal accumulated, accompanied by high rates of myocardial ferroptosis.