SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling

The authors revealed that the voltage-gated calcium channel subunit α2δ1-mediated calcium signaling could upregulate the expression of SIRT4, which was highly expressed in α2δ1-positive pancreatic tumor-initiating cells.