APOE Deficiency Inhibits Amyloid-Facilitated (A) Tau Pathology (T) and Neurodegeneration (N), Halting Progressive ATN Pathology in a Preclinical Model

Scientists studied the role of APOE in a preclinical model that robustly mimics amyloid-facilitated tau pathology and subsequent neurodegeneration generated by crossing 5xFAD and TauP301S mice.