Whole-Exome Tumor-Agnostic ctDNA Analysis Enhances Minimal Residual Disease Detection and Reveals Relapse Mechanisms in Localized Colon Cancer

The authors performed whole-exome sequencing of circulating tumor DNA (ctDNA) at different time points in participants with relapsed colon cancer in two independent cohorts, alongside transcriptomic and proteomic analyses of metastases, to enhance comprehension of progression mechanisms.