Novel Roles of Nrf3-Trim5 Axis in Vascular Smooth Muscle Cell Dysfunctions and Neointimal Hyperplasia

Transcriptome dataset and human atherosclerotic samples were used to determine nuclear factor erythroid 2-related factor 3 (Nrf3) expression levels. Global and vascular smooth muscle cell (VSMC)-specific Nrf3 knockout mice were used to assess the role of Nrf3 in VSMC function and injury-induced neointimal hyperplasia.