Nanoimmunomodulation of the Aβ-STING Feedback Machinery in Microglia for Alzheimer’s Disease Treatment

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Investigators showed that while microglia play a protective role in clearing extracellular Aβ, excessive Aβ engulfment triggers the cytosolic leakage of mitochondrial DNA for cGAS–stimulator of interferon genes (STING) cascade.
[Proceedings of The National Academy of Sciences of The United States of America]
Abstract