NEXN Regulates Vascular Smooth Muscle Cells Phenotypic Switching and Neointimal Hyperplasia

Using integrative transcriptomics analysis and smooth muscle specific lineage tracing mice, scientists demonstrated NEXN is highly expressed in vascular smooth muscle cells (VSMCs), and the expression of NEXN is significantly reduced during the phenotypic transformation of VSMCs and intimal hyperplasia induced by vascular injury.