Intracerebroventricular Bivalent CAR T Cells Targeting EGFR and IL-13Rα2 in Recurrent Glioblastoma: A Phase I Trial

Researchers reported the dose escalation and exploration phases of a Phase I trial investigating intracerebroventricular delivery of bivalent CAR T cells targeting epidermal growth factor receptor (EGFR) epitope 806 and interleukin-13 receptor alpha 2 (IL-13Rα2), or CART-EGFR-IL13Rα2 cells, in patients with EGFR-amplified recurrent glioblastoma.