SFRP1 and SFRP2 Jointly Regulate Normal and Malignant Hematopoietic Progenitors by Influencing Mesenchymal Cells in the Hematopoietic Niche

Researchers showed that secreted frizzled-related proteins 1/2 (SFRP1/2) functions as a niche factor for both normal and malignant HSPCs by acting on mesenchymal stromal cells.