Matrix-Bound EGF Promotes Malignant Phenotypes of Breast Cancer Organoids in the Biomimetic ECM of Alginate

Scientists established in vitro 3D breast cancer organoid models in the recreating tumor-stroma niche by using alginate cryogels to mimic the porous extracellular matrix (ECM), especially to introduce the controlled release of matrix-bound growth factor epidermal growth factor (EGF).