γδ+ T Cell-Derived IL-17A Stimulates Airway Epithelial/Stromal Cells to Secrete G-CSF, Promoting Lung-Specific Pathogenic Siglec-F+ Neutrophil Development in PPE-Induced Emphysema
Scientists identified a distinct population of lung-specific pathogenic Siglec-F+ neutrophils in a porcine pancreatic elastase (PPE)-induced mouse model of emphysema.