Glucose Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer

Researchers established a mouse model in which mtDNA depletion is induced by the Herpes Simplex Virus Type 1 protein UL12.5 in the brain led to an epileptic phenotype, characterized by abnormal electroencephalography patterns and increased neural excitability in hippocampus.