Role of LIMK1-Cofilin-Actin Axis in Dendritic Spine Dynamics in Alzheimer’s Disease

The authors synthesize current findings on Lin-11/Isl-1/Mec-3 domain-containing protein kinase 1 (LIMK1)-cofilin-actin signaling in Alzheimer’s disease, emphasizing the dual role of cofilin in stabilizing and severing actin filaments.