KDM4C Inhibition Blocks Tumor Growth in Basal Breast Cancer by Promoting Cathepsin L-Mediated Histone H3 Cleavage

Scientists described a unique role for the KDM4C histone lysine demethylase in KDM4C-amplified basal breast cancers, where KDM4C inhibition reshapes chromatin and transcriptomic landscapes without substantial alterations of its canonical substrates, trimethylated histone H3 lysine 9 and lysine 36.