Unraveling the Efficacy of AR Antagonists Bearing N-(4-(Benzyloxy)Phenyl)Piperidine-1-Sulfonamide Scaffold in Prostate Cancer Therapy by Targeting LBP Mutations

Researchers developed a compound, which contains an N-(4-(benzyloxy)phenyl)piperidine-1-sulfonamide scaffold through structural optimization and comprehensive screening against T878A-mutated androgen receptor.