Methylation of RBM39 by PRMT6 Enhances Resistance to Indisulam in Non-Small Cell Lung Cancer by Promoting Alternative Splicing of Proto-Oncogenes

Scientists demonstrated that hypermethylation of RNA-binding protein 39 (RBM39), a specific target of Indisulam, is closely associated with Indisulam resistance. Protein arginine methyltransferase 6 (PRMT6) methylates RBM39 at R92.