Systemic Delivery of Cadherin 17-Specific CAR T Cells Allows Effective and Safe Targeting of Colorectal Cancer Liver Metastases

The authors identified cadherin-17 (CDH17) as a candidate antigen for CAR T cell therapy of colorectal cancer (CRC) liver metastases. When used in a CRC liver xenograft model, CDH17 CAR T cells efficiently suppress tumor growth upon either systemic or locoregional administration.