SMURF2 Inhibition Attenuates Cardiac Hypertrophy through Blocking Ubiquitination Degradation of AXIN1

Scientists investigated the regulatory role of SMURF2 in cardiac hypertrophy. Experiment models were established in mice by transverse aortic constriction in vivo, as well as in neonatal rat cardiomyocytes by treatment with angiotensin II in vitro.