TGFβ-dependent Signaling Drives Tumor Growth and Aberrant Extracellular Matrix Dynamics in NF1-Associated Plexiform Neurofibroma

Transcriptomic characterization of murine and human plexiform neurofibromasat bulk and single-cell resolution identified transforming growth factor–β (TGFβ) signaling as a key upstream regulator, driving aberrant basement membrane protein production by neoplastic Schwann cells and Fbs.