Piezo1 deletion enhances cross-priming of CD8⁺ T cells by tumor-infiltrating CD11b⁺ dendritic cells

Investigators described an association between mechanosensation and cross-presentation by cDC2A cells. Their findings may be impactful in improving the continued development of dendritic cell vaccines whose success hinges on proper antigen processing and presentation to cytotoxic T cells in the tumor microenvironment.