HDL-Bound S1P Affects the Subventricular Niche and Early Neuropathological Features of Alzheimer’s Disease

Using apolipoprotein M (Apom)^-/- mice, scientists showed that blood ApoM-sphingosine-1-phosphate (S1P) deficiency impairs the subventricular zone-NSC pool, neurogenesis, ependymal cell polarity, and cerebrospinal fluid flow.