TGF-β Inhibition Restores Hematopoiesis and Immune Balance via Bone Marrow EPCs in Aplastic Anemia

Scientists find that transforming growth factor-β (TGF-β) signaling is hyperactive in dysfunctional aplastic anemia endothelial progenitor cells (EPCs) with impaired hematopoietic support and immune regulatory ability, and TGF-β inhibition promotes hematopoiesis and immune rebalance by repairing dysfunctional EPCs.