Vamp3/Syntaxin 4 Mediates the Basolateral Membrane Fusion of TfR Transcytosis across the BBB and Is Exploited by Pathogenic E. coli

Investigators found that the interaction between VAMP3 on transferrin receptor (TfR) vesicles and syntaxin 4 at the basolateral membrane of brain microvascular endothelial cells mediates the final fusion step of TfR transcytosis.