Isoform-Specific Function of NSD3 in DNA Replication Stress Confers Resistance to PARP Inhibitors in Prostate Cancer

Scientists demonstrated that dysregulated ubiquitination and turnover by the cullin 3^ZBTB2 E3 ligase complex induce the upregulation of the short isoform of nuclear-receptor-binding SET domain protein 3, which confers PARPi resistance in prostate cancer cells and patient-derivedmetastatic castration-resistant prostate cancer samples.