ADH5/ALDH2 Dehydrogenases and DNA Polymerase Theta Protect Normal and Malignant Hematopoietic Cells from Formaldehyde Challenge: Therapeutic Implications

Investigators showed that DNA polymerase theta cooperates with alcohol dehydrogenase 5 (ADH5) and aldehyde dehydrogenase 2 (ALDH2) to protect healthy and malignant hematopoietic stem and progenitor cells challenged by formaldehyde.