CD8⁺GZMK⁺CD27⁺CCR7⁺ T Cells Mobilized by Splenic Sympathetic Nerves Aggravate Brain Ischemia‒Reperfusion Injury via CCL19-Positive Endothelial Cells

The authors utilized a surgical denervation protocol to perform splenic sympathetic denervation, which significantly attenuates brain injury following stroke. Ischemic injury induces endothelial cell-specific expression of CCL19, which chemoattracts stroke-associated T cells into the brain parenchyma.