The Tumor Suppressor pRb and Its Relative p130 Are Required to Maintain Murine Adult Skeletal Muscle Homeostasis

Scientists showed that targeted deletion of murine Rb in proliferating myoblasts during myogenesis, using a Pax7-Cre deleter line, leads to muscle fiber degeneration, short myotubes with elongated, large nuclei, reduced late muscle marker expression, and fetal death.