Tumor-Instructed Glutamine Synthesis in Cancer-Associated Fibroblasts Promotes Pro-Tumor Macrophages

Scientists found that glutamine synthesis by cancer-associated fibroblasts (CAFs) promotes the polarization of pro-tumorigenic tumor-associated macrophages (TAMs) and supports tumor growth by altering TAM composition, highlighting the pivotal role of CAFs in shaping the immunosuppressive tumor microenvironment.