TGF-β1-Triggered Maladaptive Bone Marrow Endothelium Impedes Hematopoietic Recovery

In vitro experiments combined with a mouse model with adeno-associated virus-mediated bone marrow endothelial cell (BM EC)-specific overexpression of constitutively active TGF-βRI demonstrated that TGF-β1 activation drives maladaptive BM ECs.