Collagen-Disrupting attIL12 TIL Therapy Boosts Deep T Cell Infiltration via Dual Signaling Activation and CCKAR Reduction in Sarcomas

Scientists found that CCKAR directly boosts collagen production by tumor cells in vitro and in vivo. attIL12-modified tumor-infiltrating lymphocytes (TILs) disabled collagen production by CCKAR-high autologous tumor cells in vitro and sarcoma patient-derived xenografts in vivo.