EZHIP Restricts Noncanonical PRC2 Binding and Regulates H3K27me3 Intergenerational Inheritance and Reprogramming

Scientists showed that PRC2, which catalyzes H3K27me3, binds both classic Polycomb targets and noncanonical H3K27me3 domains in growing oocytes but dissociates from chromatin in fully grown oocytes.